Agno vs Letta

Choose Agno if…

Best for python developers building agents that need to reason over images, audio, and video, not just text, and its edge is multi-modal by default, no special handling required for non-text inputs, unlike most agent frameworks. A genuinely readable, Pythonic way to build multi-modal agents, there's no TypeScript SDK if that's your stack. Lean toward Letta instead if manages its own memory tiers and decides what to retain or summarize, more reliable than an ad-hoc RAG memory hack matters more for your use case.

Choose Letta if…

Best for developers building agents that need to remember and update facts across arbitrarily long interaction histories, and its edge is manages its own memory tiers and decides what to retain or summarize, more reliable than an ad-hoc RAG memory hack. A genuinely more solid approach to agent memory than manual context management, per-step cloud pricing adds up for memory-heavy agents. Lean toward Agno instead if multi-modal by default, no special handling required for non-text inputs, unlike most agent frameworks matters more for your use case.